University of Bar-Ilan,
Tel Aviv, Israel. B. Sc. Biochemistry, 1976.
The Hebrew University, Hadassah
Medical School, Jerusalem, Israel. M.Sc. Biochemistry, 1979.
The Hebrew University, Hadassah
Medical School, Jerusalem, Israel. Ph.D. Biochemistry, 1984.
Thesis: Relationship Between Membrane Lipid Composition and Chemical, Physical,
and Biological Properties of Cell Membranes.
Experience
1985-1987, Post Doctoral
Fellow at the Department of Biology, Johns Hopkins University, Baltimore,
MD 21218, U.S.A. Sponsor: Dr. Michael Edidin.
1987-1988, Visiting
Associate,
Endocrinology Section, Gerontology Research Center, National Institute on Aging,
National Institutes of Health, Baltimore, MD 21224, U.S.A.
1988-1990, Visiting
Associate,
Laboratory of Biological Chemistry, Gerontology Research Center, National Institute
on Aging, National Institutes of Health, Baltimore, MD 21224, U.S.A.
1991-1992, Independent research
on funding allocation and process management for drug- discovery start-up.
1993-1996, Assistant
Professor, Department of Medicine, University of Texas Health Science
Center at San Antonio, San Antonio, TX 78284.
1997-present, Founder,
President, and Director of Research, Elsom
Research Co., Inc., San Antonio, TX 78249
2002, "Method
of Reducing Age-Related Changes in Heart Muscle Cells", for treatment
of age-related disorders. U.S.A. Patent No. 6,348,213.
1990, "Improvements
in Heart and Respiratory Function", following intravenous injection
of small unilamellar liposomes. European Patent No. EP 0 234 919 B1.
1989, "Lipid
Replacement Therapy", for treatment of age-related disorders. U.S.A.
Patent No. 4,812,314.
Patents
Pending and in Preparation
US Patent Application
09/476,013 for the development of a universal emulsification system (pending).
US Patent Application
for the development of intravenous drug delivery system.
US Patent Application
for a confocal fluorescence redistribution after photobleaching (CF-FRAP)
system to study molecular dynamics of live intact cells.
US Patent Application
for the synthesis and use of a novel lipid vehicle for cancer therapy and
cholesterol removal.
Honors
1980, "Best Lecturer
of The Year" in biochemistry, Hadassah Medical School, Jerusalem
1981, "Best Lecturer
of The Year" in biochemistry, Hadassah Medical School, Jerusalem
1982, "Best Lecturer
of The Year" in biochemistry, Hadassah Medical School, Jerusalem
1983, "Best Lecturer
of The Year" in biochemistry, Hadassah Medical School, Jerusalem
Dr. Yechiel was honored
four years sequentially as best lecturer in biochemistry by medical, dental,
and pharmacy students at Hadassah Medical School, Jerusalem, Israel. His students
petitioned the management for an exception to have Dr. Yechiel (then a graduate
student) teach them two semesters in a row instead of changing lecturers.
1984, The Annual Prize
for the Best Ph.D. Thesis. Awarded by the Faculty of Medicine, Hebrew
University, Hadassah Medical School.
Grants
Geriatric Leadership
Academic Award - Grant No. NIK K07 AG00469.
Institutional Research
Grant Award - T-RAHW-OO-208-O.
Unique
Achievements
Human trials were conducted
of Dr. Yechiel’s therapeutic inventions for treatment of respiratory disorders
and high cholesterol, at Hadassah Medical Center in Jerusalem, Israel. The treatment
is currently marketed by Infuturia Global and is available at clinics in Switzerland
and in England.
"Squidoline",
a novel compound invented by Dr. Yechiel, has proved to be 10-100 times more
effective than liposomes as a delivery vehicle for anti-cancer drugs, killing
one hundred per cent of breast cancer cells in culture. Squidoline is in patent
processing.
Associations
American Association
for the Advancement of Science
American Association
of Pharmaceutical Scientists
American Chemical Society
Publications
Barenholz, Y., and E.
Yechiel, R. Cohen, and R.J. Deckelbaum. 1981. Importance of cholesterol phospholipid
interaction in determining dynamics of normal and abetalipoproteinemia red
blood cell membranes. Cell Biophysics. 3:115-126.
Bkaily, G., N. Sperelakis,
E. Yechiel and Y. Barenholz. 1983. Effect of Na+ or Ca2+ filled
liposomes on electrical activity of cultured heart cells. Am. J. Phsiol.
245: H756-H761.
Yechiel, E., and Y. Barenholz.
1985. Relationships between membrane lipid composition and biological properties
of rat myocytes. J. Biol. Chem. 260:9123-9131.
Yechiel, E. and Y. Barenholz,
and Y.I. Henis. 1985. Lateral mobility and organization of phospholipids and
protein in rat myocyte membranes. J. Biol. Chem. 260:9132-9136.
Yechiel, E., Y.I. Henis,
and Y. Barenholz. 1986. Aging of rat heart fibroblasts; Relationship between
lipid composition, membrane organization, and biological properties Biochem.
Et Biophys. Acta. 859:95-104.
Yechiel, E., and Y. Barenholz.
1986. Cultured heart cell reaggregates: A model for studying relationship
between aging and lipid composition. Biochem. et Biophys. Acta. 859:105-109.
Moscona-Amir, E., Y.I.
Henis, E. Yechiel, Y. Barenholz, and M. Sokolovsky. 1986. Role of lipids in
age related changes in the properties of muscarinic receptors in cultured
rat heart myocytes. Biochemistry. 25:8118-8124.
Yechiel, E., and M. Edidin.
1987. Micron scale domains in fibroblast plasma membranes. J. Cell. Biol.
705: 755-760.
Yechiel, E., and Y. Barenholz.
1989. "Lipid Replacement Therapy", U.S.A. Patent No. 4.812.314.
Yechiel, E., et al.,
1990. "Improvements in Heart and Respiratory Function", following
IV injection of small unilamellar liposomes. European Patent No. EP
0 234 919 B1.
Yechiel, E. and M. Edidin.
1994. The Domain Structure of Membranes. Mobility and Proximity in
Biological Membranes CRC Press,ISBN 0-8493-4931-1, pp126-127.
Ed. M. Edidin et al.
Yechiel, E, et al., 2002,
"Method of Reducing Age-Related Changes in Heart Muscle Cells",
for treatment of age-related disorders. U.S.A. Patent No. 6,348,213.
Yechiel, E. and R. Coste.
2005. From Ancient Potions To Modern Lotions:
A Technology Overview and Introduction
to
Topical Delivery Systems.Delivery
System Handbook for Personal Care and Cosmetic Products: Technology, Applications
and Formulations. Noyes
Publications. Ed. M. R. Rosen.
Yechiel, E. 2005. Interactive
Vehicles in Synergistic Cosmeceuticals: Advances in Nano-Encapsulation,
Transportation, Transfer, and Targeting. Delivery
System Handbook for Personal Care and Cosmetic Products: Technology, Applications
and Formulations. Ed.
M. R. Rosen.
Yechiel, E. The quaternary
architecture model of the cell membrane (in preparation).
Yechiel, E. Synthesis
of a novel lipid carrier "Squidoline". Will be submitted for publication after
patent approval.
Yechiel, E. Squidoline
derivatives complex and disperse Taxol and Doxorubicin in aqueous media and
enhance their activity against breast cancer cells in culture. Will be submitted
for publication after patent approval.
Yechiel, E. "Novel Confocal
- Fluorescent Redistribution After Photobleaching (CF-FRAP) System". Will
be submitted for publication after patent approval.